CURE Special Mini Symposium: Regeneration, Inflammation and Cancer Microenvironment

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- When: Tuesday, January 17, 2017 - 12:00- 2:30 PM
- Where: VA Bldg 114 Room 125, UCLA Cure Center
- More information on: cure.med.ucla.edu
- Contact: CURE office at 310-312-9284

Deciphering Cancer-Associated Fibroblast Biology for therapeutic targeting of pancreatic adenocarcinoma

Corinne Bousquet, PhD
Research Director, INSERM DR2
UMR INSERM-1037, Toulouse University III
CRCT "Cancer Research Center of Toulouse"
Team 6 "Protein Synthesis & Secretion in Carcinogenesis"
Oncopole de Toulouse

Dr. Bousquet will provide insight on her investigations to delineate the role of the tumor microenvironment in the initiation / progression phases of pancreatic cancer using transgenic models of pancreatic ductal adenocarcinoma models derived from Pdx1-Cre;KrasG12D that presents a step-wise progression of lesions from pre-neoplastic to invasive, and primary cultures of human cancer-associated fibroblasts. She also presents the identification of stroma-derived proteins by implementing proteomic approaches. Lastly she has recent data on the tumor suppressive action of somatostatin and its receptors during pancreatic carcinogenesis, and its role as an active anti-inflammatory player at the interface between pancreatic epithelial and stromal cells, using sst1, sst2 knock-out, Pdx1-Cre;KrasG12D , and Pdx1-Cre;KrasG12D ; Trp53R172Htransgenic mouse models.

Crypt stem cells and alteration of the epithelial regeneration in ulcerative colitis

Audrey Ferrand, PhD
INSERM Researcher Scientist (CR1)
Institut de Recherche en Santé Digestive (IRSD) - France
INSERM u1220, INRA u1416, ENVT, UT3

Dr. Ferrand will address the interactions between normal or cancer stem cells and fibroblasts in the various stages of inflammation leading to colorectal tumorigenesis by combining morphological, functional, pharmacological and microfluidic approaches to 3D cell primocultures of colorectal organoids and fibroblasts, coupled to orthotopic grafting on murine models.